What Are They And Common Side Effects

Most babies receive the second dose of the two-month vaccines during the four-month visit. In addition, doctors may suggest meningococcal vaccines for babies who are at risk. Although most babies have already received the first dose of most four-month vaccines, the second dose is necessary to build stronger immunity.

The US Centers for Disease Control and Prevention and the American Academy of Pediatrics recommend giving vaccinations to babies as per schedule. Delaying or not giving vaccinations does not provide appropriate protection against vaccine-preventable diseases. Read this post to know about the four-month vaccines.

Which Immunization Shots Do Four-Month-Olds Get?

According to the Advisory Committee on Immunization Practices (ACIP) and approved by the US Centers for Disease Control and Prevention (CDC), American Academy of Pediatrics (AAP), and American Academy of Family Physicians (AAFP), second dose of the following vaccines are included in the immunization schedule of a four-month-old baby (1).

1. DTaP vaccine

DTaP vaccine is given to prevent diphtheria, tetanus, and pertussis (whooping cough) in babies. This is the newer version of the DTP vaccine with fewer side effects and more safety. DTaP vaccine contains acellular pertussis antigen (parts of pertussis bacteria) with tetanus and diphtheria toxoids (a modified toxin that is no longer toxic). The older DTP vaccines contained whole-cell pertussis and often caused severe immune reactions, and the vaccine is no longer recommended in many countries.

Toxins of Corynebacterium diphtheriae cause diphtheria. These bacteria can spread through air or direct contact and cause symptoms such as sore throat, mild fever, swollen lymph nodes in the neck, and weakness. Diphtheria may result in heart failure, coma, paralysis, or death in babies.

Clostridium tetani bacteria cause tetanus. These bacteria can enter the body through skin cuts, and their toxins cause painful muscle spasms. Stiffness in abdominal and neck muscles, swallowing problems, and fever are common symptoms of tetanus. Muscle spasms can lead to severe breathing trouble, broken bones, and death in babies.

Pertussis or whooping cough is a highly contagious respiratory disease spread from air and direct contact. A runny nose and severe cough with a pause in breathing (apnea) are the signs of pertussis infection. This may lead to severe pneumonia and death in babies.

2. Hib vaccine

Hib vaccine prevents Haemophilus influenzae type b disease in infants. Hib bacteria can spread through air or direct contact and do not cause symptoms unless they enter the bloodstream. This may cause meningitis, pneumonia, epiglottis, and death in babies.

Hib infection may also contribute to intellectual disability in the future. In many cases, epiglottitis may result in life-threatening complications such as windpipe obstruction and severe breathing troubles.

3. IPV vaccine

IPV or inactivated polio vaccine prevents polio or poliomyelitis in babies. Polio can spread from an infected person to others through the air, direct contact, or through the mouth (fecal-oral route). The infection may often go unnoticed since many can be asymptomatic or may have a fever and sore throat. Polio may cause permanent paralysis and death in unvaccinated people.

4. RV vaccine

RV or rotavirus vaccine prevents rotavirus diseases. Rotavirus is spread from the mouth (fecal-oral route) and often causes diarrhea, vomiting, and fever. Severe diarrhea and dehydration can be life-threatening to infants and young children.

5. PCV13 vaccine

PCV13 or pneumococcal conjugate vaccine protects against pneumococcal disease caused by 13 types of pneumococcal bacteria. These bacteria can spread from air or direct contact and often causes no symptoms or pneumonia (lung infection) in babies. Complications of pneumococcal diseases, such as meningitis and blood infection (bacteremia), can be life-threatening in infants.

Combination vaccines that contain more than one vaccine in a single shot are available in most countries. This reduces the number of shots and reactions in many babies. Common combination vaccines for the fourth month may include Kinrix with DTaP and IPV combination and Pentacel with DTaP, IPV, and Hib combinations. You may speak to your baby’s pediatrician to learn about the various combination vaccines available in your country or region.

Who Gets The Meningococcal Vaccine At Four Months Of Age?

The second dose of the meningococcal vaccine is given at four months to babies noted to fulfill the following special conditions (2).

  • Functional or anatomic asplenia such as sickle cell anemia
  • Use of complement inhibitor medications, such as bevacizumab or eculizumab
  • Persistent complement component deficiency

Meningococcal vaccines prevent meningococcal disease caused by Neisseia meningitidis bacteria. Babies may get MenB vaccines or serogroup B meningococcal vaccines, such as Bexsero and Trumenba.

Why Are Second Doses Of Some Vaccines Needed?

The number of doses of the particular vaccine depends on the following factors (3) (4).

  • Type of vaccine: Vaccines made from weakened viruses known as live attenuated vaccines provide immunity by reproducing at low levels in the body. Therefore, attenuated vaccines can create strong immune responses in fewer doses. In comparison, vaccines made from toxoids (inactive bacterial toxins) or some proteins may require more amounts to develop adequate immunity.
  • Immune system response: Some vaccines, such as inactivated vaccines, may not give as much immunity with the first dose, and second or more doses are required to build complete immunity. For example, a single dose of the Hib vaccine does not completely protect the baby. In addition, immune responses may fade or weaken over time in some vaccines. In such cases, a booster dose of vaccine is needed to ensure maximum immunity or protection against the disease.
  • Disease burden in the community: The amount of viral or bacterial diseases spreading in a community is directly related to how many people are susceptible (likely to get the disease). Usually, when all people are vaccinated, the amount of disease spreading in the community is less. So, an additional dose of vaccine is required to maintain immunity since the illness may appear less frequently. Thus, sometimes, additional booster doses of vaccine may be given during the outbreak to enhance immunity.

Partial vaccination does not provide complete immunity. Therefore, experts recommend giving all doses and booster doses of vaccines as per schedule to protect your baby from vaccine-preventable diseases.

What Are The Common Immune Reactions Of Four-Month Shots?

Immune reactions mean that the vaccines are working and the body is producing antibodies against the disease. Vaccines can cause temporary injection site reactions such as swelling, pain, and redness and general reactions such as fussiness and fever in most babies.

Most four-month vaccines do not cause any severe side effects or reactions in babies. Local (shot site) immunization reactions of most four-month vaccines start within 24 hours of the shot and often last up to three to five days. DTaP vaccine may cause local reactions up to seven days in some babies. Vaccine-related fever may last up to one or two days in most cases.

In rare cases, babies may experience severe reactions, such as rotavirus vaccine may cause intussusception in some cases (5). Some babies may develop severe allergic reactions called anaphylaxis within 20 minutes or up to two hours after the vaccination. Therefore, parents are advised to wait for 30 minutes after vaccinations since vaccine administrators are trained to handle such situations and treat anaphylaxis immediately.

When To See A Pediatrician?

You may contact the pediatrician if you think that your baby requires emergency help for immune reactions. Seek help from a pediatrician if your baby has any of the following problems after immunization (5).

  • Breathing trouble
  • Swallowing problems
  • Weakness
  • Not moving or responding
  • Unable to wake up
  • Persistent crying lasting several hours
  • High-pitched crying for more than an hour
  • Severe crying and vomiting after rotavirus vaccine
  • Fever over 40°C (104°F)
  • Increase in redness and swelling at the injection site

It is not recommended to give fever medications to babies before being examined. You may seek pediatric help to manage fever in babies.

Are There Any Reasons Not To Get Four-Month Shots?

Vaccines are not administered if any contraindications are present. Contraindications are health conditions in the baby that increase the chance of severe adverse reactions to a vaccine. Four-month vaccines and other vaccines are not given if any of the following permanent contraindications are present (6).

  • Anaphylaxis is a severe allergic reaction to a vaccine component. All vaccines containing the same component and the subsequent doses of the same vaccine are not given to babies with known anaphylaxis.
  • History of intussusception is contraindication to administer rotavirus vaccine.
  • Encephalopathy occurring within seven days of pertussis vaccine with no other identifiable cause is a contraindication to give a subsequent dose of pertussis-containing vaccine.
  • SCID (severe combined immunodeficiency) is a contraindication to give a rotavirus vaccine.

These four conditions are the only permanent contraindications to vaccination. Immunosuppression is a temporary contraindication to immunization with live vaccines.

Four-month vaccines can be deferred or delayed for some babies due to precautions. These are health conditions that may increase the chance of an adverse reaction, cause diagnostic confusion, or compromise the ability of vaccines to produce a desired immune response. If precautions are present, pediatricians may decide whether to vaccinate or not based on the risks and benefits of the vaccine.

Permanent precautions to four-month vaccines may include (6):

  • Spina bifida, altered immunocompetence other than SCID, bladder exstrophy (birth defect with bladder developed outside), and chronic gastrointestinal diseases are precautions to administer rotavirus vaccine.
  • Guillain-Barré syndrome (GBS) happens six weeks or less after a previous tetanus immunization or other tetanus toxoid-containing vaccines.

Temporary precautions to four-month vaccines and other vaccines may include (6):

  • Severe or moderate acute illness.
  • Progressive neurologic disorders such as uncontrolled epilepsy, infantile spasms, and progressive encephalopathy.
  • Arthus-type hypersensitivity reaction to two-month (or previous dose) of diphtheria toxoid or tetanus toxoid vaccine.

The risk-benefit decision is taken if precautions are present. For example, family history of adverse reactions unrelated to SIDS (sudden infant death syndrome), immunosuppression, or seizures is not contraindicated for four-month vaccines.

The following conditions are often misinterpreted as contraindications or precautions (invalid contraindications or precautions to vaccination) to four-month and other childhood vaccines (6).

  • Mild illness such as low-grade fever, mild diarrhea, cold, other upper respiratory tract infections, or otitis media (ear infection).
  • Allergies to the products in vaccines those are not anaphylactic.
  • Allergies to products not present in the vaccine.
  • Antimicrobial therapy does not influence the immune response to vaccines. Antivirals may need precaution in some vaccines, but they do not interfere with four-month vaccines.
  • Household contact with immunosuppressed persons, pregnant, or breastfeeding mothers.
  • Preterm birth is not a contraindication to vaccination. Preemies are vaccinated based on their chronological age.
  • The use of aerosolized steroids for asthma is not a contraindication to vaccines.

You may talk to the pediatrician to know when your baby can get the delayed dose of four-month vaccines if any of them are postponed due to temporary contraindications or precautions.

What Else Should You Expect At A Four-Month Infant Appointment?

The pediatrician may weigh your baby and measure their length during the four-month checkup to ensure their growth. They may also look for other age-appropriate developments and reflexes in your baby. Doctors may evaluate and ask a few questions to understand the baby’s development. The following signs of development are usually assessed during the four-month infant visit.

  • Making sounds and laughing
  • Responding to caregivers or parents voices
  • Smiling
  • Trying to grab things
  • Making eye contact
  • Sucking hands or fingers
  • Copying facial expressions
  • Holding up head
  • Trying to roll over
  • Turning head towards parent or caregiver
  • Pushing up while lying on their tummy
  • Feeding and diaper change frequency

These factors may help the doctor understand whether your baby is reaching their four-month milestones or not. They may also ask about your travel plans and childcare centers to suggest the best ways to keep your little one healthy.

Vaccines help to protect babies against many dangerous diseases. Immune reactions are an indication that the vaccine is doing its work in the baby’s body. Most vaccine reactions, such as pain, swelling, and fever, go away within a short time, while not vaccinating can increase the chances of getting diseases that cause permanent disabilities or death. Never delay vaccinating your baby, and stick to the recommended schedule. You may ask the pediatrician if you have any doubts regarding vaccines’ efficacy and safety of childhood vaccines in general.


MomJunction’s health articles are written after analyzing various scientific reports and assertions from expert authors and institutions. Our references (citations) consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.

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